[Fitness & Nutrition] Most of all are super visuals 👁. We are...

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Most of all are super visuals 👁. We are drawn to what catches our eyes👀, weather is a pair of shoes👠, a shiny car🚗, or the dish printed on a Chili's menu🍔.
But what about our ears👂🏼? I haven't been to the first #FancyRestaurant that has pictures on their menus. Instead, the super trained waiter/waitress 👩🏻‍🍳👨🏼‍🍳translates simple words into the most orgasmic experience. We let all the words and tones, and expressions to take us away and "beg" for tonight's special not caring about the...
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[Public Health] Glaucoma is a common disorder that is associated...

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Glaucoma is a common disorder that is associated with high pressure inside the eye. If not treated, it can lead to blindness. To lower the eye pressure, first see an eye doctor. Exercise regularly, lower your blood pressure and stress, and eat a healthy diet that consist of vitamins.

Read more: http://ow.ly/ztMk30fgjPL

#eyes #Glaucoma #eyepressure #eyedoctor #eyeexercise #bostoneyecarecenter #bostonlaser #lasikboston #bostonopthalmologist
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[Public Health] U.S. Goverment Finally Admits Marijuana ...

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Marijuana
Danielle Claudine Ortega:
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U.S. Government Finally Admits Marijuana Really Does Kill Cancer Cells
Apparently, the fact that cannabis successfully destroys cancer cells is no longer a conspiracy theory in the U.S. Therefore, can we rega...

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[Public Health] Entra y observa el contenido de la pagina...

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Entra y observa el contenido de la pagina si te gusta brindarnos un like para mas contenido de calidad
https://goo.gl/LBJtPs
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Top infomaki
Top infomaki. 2 Me gusta · 2 personas están hablando de esto. Aquí encontraras, noticias, vídeo graciosos, consejos de salud, entretenimiento y muc...

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[Public Health] Have you ever heard of wild lettuce? It ...

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Have you ever heard of wild lettuce? It is an incredible natural replacement for toxic pain relievers as well as anxiety pills
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Wild Lettuce: The Best Natural Painkiller, More Effective Than Morphine! - USA News Mag
Wild Lettuce: The Best Natural Painkiller, More Effective Than Morphine!...Wild Lettuce: The Best Natural Painkiller, More Effective Than Morphine!...

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[Public Health] Combination Of Honey And Sesame That Cures...

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Combination Of Honey And Sesame That Cures More Than 10 Diseases
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Combination Of Honey And Sesame That Cures More Than 10 Diseases | IneffableGirl
Combination Of Honey And Sesame That Cures More Than 10 Diseases...Combination Of Honey And Sesame That Cures More Than 10 Diseases...

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[Public Health] #ENT doctors are trained in the medical ...

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#ENT doctors are trained in the medical subspecialty of #otolaryngology which incorporates the clinical and surgical procedures of treating diseases associated with the aforesaid areas of the body. See More: https://drpauldrago.quora.com/Common-Facts-Of-Otolaryngology
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[Public Health] Would it surprise you if I said that many...

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Would it surprise you if I said that many of you have probably eaten raw eggs without even knowing it?
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Can eating raw eggs cause salmonella? The idea of eating raw eggs is scary to many people, because our fears of salmonella poisoning have been heig...

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[Fitness & Nutrition]

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[Public Health]

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Most Trending Ankara Style's In 2017
What you are wearing is not yet a style if you don't catch a eye watching you, Fashion is best if your style never go outdated. See 2017 latest clo...

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[Public Health] Prepare your body for next summer season

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Prepare your body for next summer season
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Prepare your body for summer season - Daily Motivation
Summer ends very soon and for some of you, ashamed of your body, it is really good time to hit the gym IT'S NOT ROCKET SCIENCE. Summer bodies are m...

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[Fitness & Nutrition] Gym Hair Hacks

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Gym Hair Hacks
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5 Ingenious Hair Hacks To Run Smoothly To A Healthy And Fit You
We all know it's not that easy to manage your hair during a workout. So we've gathered together 5 of the best hair hacks for your gym time.

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[Fitness & Nutrition] *Yoga Magic Morning: Powerful Rituals for...

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Yoga Magic Morning: Powerful Rituals for Your Best Day [Udemy Free Course]
Udemy - Yoga Magic Morning: Powerful Rituals for Your Best Day  Discount - Free Lectures 15 Length 1.5 hours Skill Levels Beginner Levels Languages English Published 9/2017 Take this course! What Will I Learn? Create a magical morning routine with life-enha...

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[Public Health] Nowadays, one of the most common problems...

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Nowadays, one of the most common problems affecting above all the western and rich countries is the obesity and, for this, the research of best #supplements for #weightloss is became very popular.
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Herbs And Teas: The Best Supplements For Weight Loss
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[Fitness & Nutrition] http://theachieversworld.com/hypothyroidism...

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Hypothyroidism: symptoms,causes and treaments - The Achievers World
Hypothyroidism is a very common disorder in which thyroid gland does not produce thyroid hormones or thyroid hormones production is blow normal.

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 What Should We All Know About Steroids and Antibiotics?

 

 

 
   
 
 
 

What Should We all Know About Steroids and Antibiotics?

Since the dawn of the internet, obtaining information has become progressively more convenient. With this convenience, we must exercise caution, as claims and medical advise abound. ITSAN strives to provide clear information from scholarly material on topics relevant within the dermatology community.

Topical steroids and antibiotics are two of the most impacting discoveries in medical history. Used with care and wise time frames, they can be effective. However, using for extended periods of time, often presents undesired consequences.


Here is a brief history of topical steroids.

• 1935: Discovery of compound E (cortisone)
• 1948: First reported use of cortisone and adrenocorticotropic hormone (ACTH) in the treatment of rheumatoid arthritis
• 1951: First report of cortisone and ACTH used in the treatment of inflammatory dermatoses
• 1952: First report of using compound F (hydrocortisone) topically

"Corticosteroids are synthetic relatives of the hormones produced by the adrenal glands, such as cortisone. Since the mid-1950s, there have been numerous modifications of the corticosteroid molecule that have dramatically increased the potency of this topical therapy (i.e., halogenation, esterification, hydroxylation, modification of side chains, and improvements in delivery systems). As the potency of the molecule has increased, so has the likelihood of side effects."
https://clinicalgate.com/topical-steroids/

https://www.nps.org.au/australian-prescriber/articles/the-role-of-corticosteroids-in-dermatology

The amazing discovery of antibiotics can be traced way back to the early world. "The traces of tetracycline, for example, have been found in human skeletal remains from ancient Sudanese Nubia dating back to 350–550 AD."  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109405/

Andrew Fleming discovered the first true antibiotic, penicillin, on September 3, 1928. He noticed his one of his petri dishes containing staphylococcus bacteria, had mold and that particular area was clear. From there, a whole new door opened to the world of antibiotics that would save thousands of lives and restore health to multitudes. 
 https://www.acs.org/content/acs/en/education/whatischemistry/landmarks/flemingpenicillin.html


The combining of antibiotics with topical steroids has been practiced and believed to be an effective way to control  serious eczema flares due to the Staphylococcus aureus bacteria exacerbating the condition. However, this has been controversial in the medical community as these conflicting studies show. 

1976-"No side-effects occurred with any drug combination use. In the opinion of the authors halcinonide-neomycin-amphotericin cream and ointment are safe and effective in the treatment of cutaneous candiasis and steroid-responsive dermatoses."
https://www.ncbi.nlm.nih.gov/pubmed/799995


2000-"Topical antibacterial-corticosteroid combinations can be useful when treating small areas of skin for a limited period of time but are accompanied by the risk of sensitization and the emergence of resistant strains of bacteria. Systemic antibacterials in combination with topical corticosteroid are more appropriate when larger areas are involved."
https://link.springer.com/article/10.2165/00128071-200001040-00002

2008-"Eczema of all types frequently becomes infected with S. aureus, and infection may exacerbate the eczema, making it less responsive to topical corticosteroids. The short-term use of a fusidic acid corticosteroid combination preparation effectively controls infection without risk of drug resistance developing. In the author's clinic, all patients referred with eczema are treated with daily baths, emollients, moisturizers and cyclical 2-week treatments with a fusidic acid/corticosteroid preparation of suitable strength alternating with corticosteroid alone. Where xerosis is a particular problem, the new formulation of fusidic acid/betamethasone in a lipid cream would be indicated."
http://file:///home/chronos/u-274081b779074301fb0d2ecc8f9c368792659eca/Downloads/8821628%20(2).pdf

2016-"Our data suggest that oral and topical antibiotics have no effect, or a harmful effect, on subjective eczema severity in children with clinically infected eczema in the community." 
https://www.ncbi.nlm.nih.gov/pubmed/26938214

2017-"We found rapid resolution in response to topical steroid and emollient treatment and ruled out a clinically meaningful benefit from the addition of either oral or topical antibiotics. Children seen in ambulatory care with mild clinically infected eczema do not need treatment with antibiotics."
https://www.ncbi.nlm.nih.gov/pubmed/28289111

2017-"There were no statistically significant differences in treatment response (i.e., proportion of patients who had improvement in symptoms or signs) between topical antibiotics (i.e., fusidic acid, mupirocin, gentamycin, retapamulin) plus corticosteroids (i.e., hydrocortisone, betamethasone, clobetasone) and corticosteroids alone at the end of treatment. One RCT (Randomiized Controlled Trials) found that there was no difference in the cure rate between two different combinations of topical antibiotics and steroids (i.e., fusidic acid plus halomethasone versus neomycin plus betamethasone). One RCT included in the SR (Systemic Review) showed that the combination of neomycin and betamethasone was even inferior to clobetasol. The combination of topical steroid, antibiotic and antifungal (i.e., halcinonide, neomycin and nystatin) also showed no significant difference for the improvement in symptoms of eczema rated by patients or medical practitioners compared with topical steroid (i.e.,hydrocortisone)." 
https://www.cadth.ca/sites/default/files/pdf/htis/2017/RC0852_Topical%20Antibiotics%20for%20Infected%20Dermatitis%20Final.pdf

This Mayo Clinic study reveals a risk of increased amounts of staph by using topical steroids. 
"Glucocorticoid use was associated with a substantially increased risk of CA-SAB. The risk increased with higher cumulative dose, revealing a distinct dose-response relation."
http://www.mayoclinicproceedings.org/article/S0025-6196%2816%2930145-8/fulltext

How long to use antibiotic/topical steroid combos? 
NICE (National Healthcare for Excellence) recommends that topical antibiotics, including those in combination with topical steroids, should only be used for short periods (less than 14 days) in cases of clinically infected eczema. However, there is no clear evidence that the addition of antibiotics to topical corticosteroids offers any advantage over topical corticosteroids alone, and they are not recommended in noninfected eczema."
http://onlinelibrary.wiley.com/doi/10.1002/psb.1428/pdf


The widespread and highly publicized threat of "super bugs" due to multiple uses of antibiotics ranging from health issues to food producing livestock, demands that the medical community find alternative ways to decolonize bacteria. This has become a major quest for the World Health Organization (WHO). 
http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/

 

"Antibiotics are among the most commonly prescribed drugs used in human medicine and can be lifesaving drugs.  However, up to 50% of the time antibiotics are not optimally prescribed, often done so when not needed, incorrect dosing or duration." 
https://www.cdc.gov/drugresistance/about.html


"Bacteria have been part of the normal human microflora for eons and usually do not cause signs or symptoms of infection. This colonization is most common in body sites such as the nose, skin, and gastrointestinal tract. The body sites of colonization are usually specific to the type of bacteria. 

The Centers for Disease Control and Prevention (CDC) report "Antibiotic Resistance Threats in the United States, 2013" highlights that at least two million Americans acquire severe antibiotic-resistant infections each year, which results in 23,000 deaths annually. Most deaths occur in health care settings such as hospitals. That CDC report recommends attempting to prevent these infections through appropriate antibiotic use and infection prevention practices
.  Healthcare Associated Infections (HAI) are now the fifth leading cause of death in U.S. acute-care hospitals."
http://cmr.asm.org/content/29/2/201.full

 
   
 
 
 
What is the Balance? 
In regards to topical steroids and antibiotics, medicine, "more" should not be confused for "better." We must rely on not just one but repeated studies to come to solid conclusions on such commonly used drugs. There is a growing agreement among conventional doctors that seeking non-drug alternatives first, may be a safer route to go. This approach needs balance as well, as serious health issues could result from not being treated adequately.

The link below describes alternatives to conventional therapy, studied for effectiveness in decreasing bacterial load and improving skin conditions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518179/
.nih.gov/books/NBK92761/

**Caution: Alternative or Chinese medicine (TCM): Please be aware that labeling is often incomplete or incorrect, and ingredients are not often fully disclosed. An independent lab test of a popular TCM cream, (led by the RSS community) revealed hidden, high potency topical steroids--amidst adamant claims to the contrary from the TCM practitioner. Be aware that some TCM components require animal cruelty to obtain. Try to educate yourself and be your own advocate before believing unsubstantial claims. If it seems to be true, it probably is. **

The results of following study (linked below), "demonstrate that wounding of the skin alone, without the presence of microbes, is sufficient to activate defense mechanisms in the skin that can prevent microbial growth and related harmful skin infections."
https://www.sciencedaily.com/releases/2006/06/060616130748.htm?utm_medium=cpc&utm_campaign=ScienceDaily_TMD_1&utm_source=TMD
 
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